Design of ocular drug delivery platforms and in vitro - in vivo evaluation of riboflavin to the cornea by non-interventional (epi-on) technique for keratoconus treatment

AYTEKİN E., ÖZTÜRK N., VURAL İ., POLAT H. K., Çakmak H. B., ÇALIŞ S., ...Daha Fazla

JOURNAL OF CONTROLLED RELEASE, cilt.324, ss.238-249, 2020 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 324
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.jconrel.2020.05.017
  • Dergi Adı: JOURNAL OF CONTROLLED RELEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Compendex, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.238-249
  • İnönü Üniversitesi Adresli: Evet

Özet

Aim: Keratoconus is a common and progressive eye disease characterized by thinning and tapering of the cornea. This degenerative eye disease is currently treated in the clinic with an interventional technique ("epi-off") that can cause serious side effects as a result of the surgical procedure. The aim of this project is to design innovative formulations for the development of a riboflavin-containing medicinal product to develop a non-invasive ("epi-on") keratoconus treatment as an alternative to current treatment modalities.