Serum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activity

EVEREKLİOĞLU, CEM; Inaloz, HS; Kirtak, N; Doganay, S; Bulbul, M; Otlu, BARIŞ; Ozerol, ELİF; Er, H; Ozbek, E

doi:10.1046/j.1365-2133.2002.04703.x

Serum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activity

EVEREKLİOĞLU C., Inaloz H., Kirtak N., Doganay S., Bulbul M., Otlu B., ...Daha Fazla

BRITISH JOURNAL OF DERMATOLOGY, cilt.147, sa.2, ss.331-336, 2002 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 147 Sayı: 2
Basım Tarihi: 2002
Doi Numarası: 10.1046/j.1365-2133.2002.04703.x
Dergi Adı: BRITISH JOURNAL OF DERMATOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.331-336
Anahtar Kelimeler: Behcet's syndrome, chronicity, disease activity, leptin, PLASMA LEPTIN, DYSFUNCTION, HUMANS, GENE
İnönü Üniversitesi Adresli: Evet

Özet

Background Behcet's syndrome is a systemic, relapsing immuno-inflammatory disease with a generalized vasculitis of the microvasculature endothelial dysfunction. Leptin, a recently discovered neuroendocrine hormone, is a metabolic peptide that appears to be involved. Serum proinflammatory cytokines upregulate leptin levels and leptin itself directly induces nitric oxide production from endothelial cells with its specific receptors.