Serum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activity

EVEREKLİOĞLU C., Inaloz H., Kirtak N., Doganay S., Bulbul M., Otlu B., ...Daha Fazla

BRITISH JOURNAL OF DERMATOLOGY, cilt.147, sa.2, ss.331-336, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 147 Sayı: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1046/j.1365-2133.2002.04703.x
  • Dergi Adı: BRITISH JOURNAL OF DERMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.331-336
  • Anahtar Kelimeler: Behcet's syndrome, chronicity, disease activity, leptin, PLASMA LEPTIN, DYSFUNCTION, HUMANS, GENE
  • İnönü Üniversitesi Adresli: Evet

Özet

Background Behcet's syndrome is a systemic, relapsing immuno-inflammatory disease with a generalized vasculitis of the microvasculature endothelial dysfunction. Leptin, a recently discovered neuroendocrine hormone, is a metabolic peptide that appears to be involved. Serum proinflammatory cytokines upregulate leptin levels and leptin itself directly induces nitric oxide production from endothelial cells with its specific receptors.