Serum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activity


EVEREKLİOĞLU C., Inaloz H., Kirtak N., Doganay S., Bulbul M., Otlu B., ...More

BRITISH JOURNAL OF DERMATOLOGY, vol.147, no.2, pp.331-336, 2002 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 147 Issue: 2
  • Publication Date: 2002
  • Doi Number: 10.1046/j.1365-2133.2002.04703.x
  • Journal Name: BRITISH JOURNAL OF DERMATOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.331-336

Abstract

Background Behcet's syndrome is a systemic, relapsing immuno-inflammatory disease with a generalized vasculitis of the microvasculature endothelial dysfunction. Leptin, a recently discovered neuroendocrine hormone, is a metabolic peptide that appears to be involved. Serum proinflammatory cytokines upregulate leptin levels and leptin itself directly induces nitric oxide production from endothelial cells with its specific receptors.