Serum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activity


EVEREKLİOĞLU C., Inaloz H., Kirtak N., Doganay S., Bulbul M., Otlu B., ...Daha Fazla

BRITISH JOURNAL OF DERMATOLOGY, cilt.147, ss.331-336, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 147 Konu: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1046/j.1365-2133.2002.04703.x
  • Dergi Adı: BRITISH JOURNAL OF DERMATOLOGY
  • Sayfa Sayıları: ss.331-336

Özet

Background Behcet's syndrome is a systemic, relapsing immuno-inflammatory disease with a generalized vasculitis of the microvasculature endothelial dysfunction. Leptin, a recently discovered neuroendocrine hormone, is a metabolic peptide that appears to be involved. Serum proinflammatory cytokines upregulate leptin levels and leptin itself directly induces nitric oxide production from endothelial cells with its specific receptors.