Beneficial effects of curcumin and capsaicin on cyclophosphamide-induced premature ovarian failure in a rat model

MELEKOĞLU R., ÇİFTÇİ O., Eraslan S., Cetin A., BAŞAK TÜRKMEN N.

JOURNAL OF OVARIAN RESEARCH, cilt.11, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1186/s13048-018-0409-9
  • Dergi Adı: JOURNAL OF OVARIAN RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Capsaicin, Curcumin, Cyclophosphamide, Premature ovarian failure, FERTILITY PRESERVATION, CHEMOTHERAPY, TOXICITY, CHLORIDE, STRESS, INJURY
  • İnönü Üniversitesi Adresli: Evet

Özet

Background: In recent years, cancer rates have been rising among reproductive-age women. Thus, chemotherapy exposure has become an important cause of premature ovarian failure (POF). There has been growing interest regarding the preservation and restoration of ovarian function before and after oncological treatment because of the reproductive risk of chemotherapeutics and improved long-term survival of cancer patients. In this study, we sought to analyze the effects of curcumin (CRC) and capsaicin (CPS) on cyclophosphamide-induced POF in a rat model.