A Series of New Hydrazone Derivatives: Synthesis, Molecular Docking and Anticholinesterase Activity Studies


BOZBEY İ., ÖZDEMİR Z. , Uslu H., ÖZÇELİK A. B. , ŞENOL F. S. , ERDOĞAN ORHAN İ., ...Daha Fazla

MINI-REVIEWS IN MEDICINAL CHEMISTRY, cilt.20, ss.1042-1060, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 20 Konu: 11
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1389557519666191010154444
  • Dergi Adı: MINI-REVIEWS IN MEDICINAL CHEMISTRY
  • Sayfa Sayıları: ss.1042-1060

Özet

Background: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is a significant neurotransmitter for regulation of cognition in animals. Inhibition of cholinesterases is an effective method to curb Alzheimer's disease, a progressive and fatal neurological disorder.