Atıf İçin Kopyala
BOZBEY İ., ÖZDEMİR Z., Uslu H., ÖZÇELİK A. B., ŞENOL F. S., ERDOĞAN ORHAN İ., ...Daha Fazla
MINI-REVIEWS IN MEDICINAL CHEMISTRY, cilt.20, sa.11, ss.1042-1060, 2020 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
20
Sayı:
11
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Basım Tarihi:
2020
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Doi Numarası:
10.2174/1389557519666191010154444
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Dergi Adı:
MINI-REVIEWS IN MEDICINAL CHEMISTRY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
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Sayfa Sayıları:
ss.1042-1060
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Anahtar Kelimeler:
Alzheimer's disease, AChE inhibitor, BChE inhibitor, 3(2H)-Pyridazinone, hydrazone, molecular docking, ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE, DESIGN, INHIBITION, NARINGENIN, ANALOGS, COMPLEX, MTDLS
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İnönü Üniversitesi Adresli:
Evet
Özet
Background: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is a significant neurotransmitter for regulation of cognition in animals. Inhibition of cholinesterases is an effective method to curb Alzheimer's disease, a progressive and fatal neurological disorder.