A 63-year-old women had an extensive limbal papilliform tumoural lesion of her left eye. Mitomycin C (MMC) was applied to thearea at a dose of 0.2 mg/ml after total surgical excision of the lesion. The lesion was diagnosed as invasive squamous cell carcinoma on histopathology and topical 0.02% MMC was prescribed four times daily to the left eye. A severe periocular contact dermatitis of the left eye developed two days after starting MMC. The patch test result was positive. The periocular dermatitis resolved after discontinuation of the topical MMC and treatment with a topical corticosteroid.