Electrochemical and in silico study of the interaction between phenazopyridine and bovine serum albumin

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Kazıcı D., Alagöz M. A., Kuyumcu Savan E.

POLYMER BULLETIN, cilt.81, sa.1, ss.661-677, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 81 Sayı: 1
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1007/s00289-023-04727-3
  • Dergi Adı: POLYMER BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Sayfa Sayıları: ss.661-677
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İnönü Üniversitesi Adresli: Evet

Özet

In this study, an electrochemical sensor was developed using a simple methodology to investigate for the first time the interaction of phenazopyridine with bovine serum albumin (BSA). The modified sensor was fabricated by electropolymerized diphenylamine-4-sulfonic acid barium salt onto the glassy carbon electrode surface by the cyclic voltammetry technique. Very low detection limit and quantification limit values were obtained by differential pulse voltammetry (DPV) in 0.1 M NaClO4 as 0.13 µM and 0.43 µM, respectively. In addition, the interference effect was studied, and recovery studies were performed in urine samples achieving dramatic recovery values. Selective and reproducible determinations of phenazopyridine were performed perfectly with the developed sensor. The reduction in BSA oxidation signals as measured by DPV upon incubation with different phenazopyridine concentrations indicated that …