Electrochemical and in silico study of the interaction between phenazopyridine and bovine serum albumin

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Kazıcı D., Alagöz M. A., Kuyumcu Savan E.

POLYMER BULLETIN, vol.81, no.1, pp.661-677, 2024 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 81 Issue: 1
  • Publication Date: 2024
  • Doi Number: 10.1007/s00289-023-04727-3
  • Journal Name: POLYMER BULLETIN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Page Numbers: pp.661-677
  • Inonu University Affiliated: Yes

Abstract

In this study, an electrochemical sensor was developed using a simple methodology to investigate for the first time the interaction of phenazopyridine with bovine serum albumin (BSA). The modified sensor was fabricated by electropolymerized diphenylamine-4-sulfonic acid barium salt onto the glassy carbon electrode surface by the cyclic voltammetry technique. Very low detection limit and quantification limit values were obtained by differential pulse voltammetry (DPV) in 0.1 M NaClO4 as 0.13 µM and 0.43 µM, respectively. In addition, the interference effect was studied, and recovery studies were performed in urine samples achieving dramatic recovery values. Selective and reproducible determinations of phenazopyridine were performed perfectly with the developed sensor. The reduction in BSA oxidation signals as measured by DPV upon incubation with different phenazopyridine concentrations indicated that …