Synthesis, characterization and antimicrobial activity of new silver complexes with N-heterocyclic carbene ligands

ÖZDEMİR İ., DEMIR S., GÜNAL S., ÖZDEMİR İ., Arici C., Ulku D.

INORGANICA CHIMICA ACTA, cilt.363, sa.14, ss.3803-3808, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 363 Sayı: 14
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.ica.2010.07.034
  • Dergi Adı: INORGANICA CHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3803-3808
  • Anahtar Kelimeler: Silver(I), Antimicrobial, Benzimidazol-2-ylidene, N-heterocyclic carbene, Medicinal inorganic chemistry, RING-OPENING POLYMERIZATION, CROSS-COUPLING REACTIONS, C-H ACTIVATION, METATHESIS CATALYSTS, OLEFIN METATHESIS, METAL-COMPLEXES, SILVER(I)-CARBENE COMPLEXES, EFFICIENT CATALYSTS, TRANSITION-METALS, ARYL CHLORIDES
  • İnönü Üniversitesi Adresli: Evet

Özet

Synthesis, structure, and antimicrobial studies of silver complexes of N-heterocyclic carbene (NHC) are reported. All the silver-NHC complexes (1a-f) were prepared from the benzimidazolium salts by the reactions with Ag2O in dichloromethane as a solvent at room temperature. The new compounds characterized by H-1 NMR, C-13 NMR, IR and elemental analysis techniques which support the proposed structures. Chloro[1-(2,4,6-trimethylbenzyl)-3-(methoxyethyl) benzimidazol-2-ylidene] silver(I) complex was structurally characterized by single-crystal X-ray diffraction. A series of new Ag-NHC complexes were screened for their in vitro antimicrobial activity against a variety of Gram-positive and Gram-negative bacteria as well as for their antifungal activity against a Candida albicans and Candida tropicalis. (c) 2010 Elsevier B. V. All rights reserved.