A light microscopic investigation of the renoprotective effects of alpha-lipoic acid and alpha-tocopherol in an experimental diabetic rat model

Kustepe E. K. , BAHAR L., ZAYMAN E. , SUCU N., GÜL S. , GÜL M.

BIOTECHNIC & HISTOCHEMISTRY, cilt.95, ss.305-316, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 95 Konu: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/10520295.2019.1695942
  • Sayfa Sayıları: ss.305-316


We investigated the effects of alpha-lipoic acid (AL) and alpha-tocopherol (AT) on renal histopathology in a streptozotocin (STZ) induced diabetic rat model. Adult male rats were divided into six groups: group 1, saline only; group 2, AL only; group 3, AT only; group 4, STZ only; group 5, STZ + AL; group 6 STZ + AT. Experimental diabetes was induced by STZ. AL and AT were administered for 15 days. Kidney sections were examined using a light microscope after hematoxylin and eosin (H & E), periodic acid-Schiff (PAS) and caspase-3 staining. Histological damage to glomeruli, tubule epithelial cells and basement membrane was observed in group 4. Administration of AT and AL reduced renal injury in the diabetic rats. Group 5 exhibited a greater curative effect on diabetic rats than group 6. AT and AL may be useful for preventing diabetic renal damage.