A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats

Sahin, Nurhan; Akdemir, FATİH; Orhan, Cemal; Aslan, Abdullah; Agca, Can; Gencoglu, Hasan; Ulas, Mustafa; Tuzcu, Mehmet; Viyaja, Juturu; Komorowski, James; Sahin, Kazim

doi:10.1179/1476830512y.0000000018

A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats

Sahin N., Akdemir F., Orhan C., Aslan A., Agca C. A., Gencoglu H., ...Daha Fazla

NUTRITIONAL NEUROSCIENCE, cilt.15, sa.5, ss.42-47, 2012 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 15 Sayı: 5
Basım Tarihi: 2012
Doi Numarası: 10.1179/1476830512y.0000000018
Dergi Adı: NUTRITIONAL NEUROSCIENCE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.42-47
İnönü Üniversitesi Adresli: Evet

Özet

Aims: A novel nutritional supplement complex (N21 #125) composed of four well-known compounds (chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron) was designed to improve memory function and maintain brain health. The present study evaluated the complex's potential mechanism of action and its role in reducing oxidative stress in the brain of obese rats fed a high-fat diet (HFD).