A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats

Sahin, Nurhan; Akdemir, FATİH; Orhan, Cemal; Aslan, Abdullah; Agca, Can; Gencoglu, Hasan; Ulas, Mustafa; Tuzcu, Mehmet; Viyaja, Juturu; Komorowski, James; Sahin, Kazim

doi:10.1179/1476830512y.0000000018

A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats

Sahin N., Akdemir F., Orhan C., Aslan A., Agca C. A., Gencoglu H., ...More

NUTRITIONAL NEUROSCIENCE, vol.15, no.5, pp.42-47, 2012 (SCI-Expanded)

Publication Type: Article / Article
Volume: 15 Issue: 5
Publication Date: 2012
Doi Number: 10.1179/1476830512y.0000000018
Journal Name: NUTRITIONAL NEUROSCIENCE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.42-47
Inonu University Affiliated: Yes

Abstract

Aims: A novel nutritional supplement complex (N21 #125) composed of four well-known compounds (chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron) was designed to improve memory function and maintain brain health. The present study evaluated the complex's potential mechanism of action and its role in reducing oxidative stress in the brain of obese rats fed a high-fat diet (HFD).