Analysis of prognostic factors in grade 3 endometrioid type endometrial carcinoma.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası:
- Basım Tarihi: 2022
- Doi Numarası: 10.1002/ijgo.14277
- Dergi Adı: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Gender Studies Database, MEDLINE, Public Affairs Index
- Anahtar Kelimeler: endometrial cancer, Grade3, prognostic factor, LYMPHOVASCULAR SPACE INVASION, CERVICAL STROMAL INVASION, LYMPH-NODE METASTASIS, RECURRENCE PATTERNS, HISTOLOGIC GRADE, SURVIVAL, CANCER, CA-125, DEPTH
- İnönü Üniversitesi Adresli: Evet
Özet
Objective To investigate the prognostic factors of patients with Grade 3 endometrioid endometrial cancer (G3EEC). Methods This four-center, retrospective study included a total of 129 women with G3EEC. Demographic, clinicopathologic, and survival data were collected. Kaplan-Meier method was used for survival analysis. Predictors of outcome were analyzed using Cox proportional hazards models. Results Median age at the time of diagnosis was 63 (range 39-87) years and median follow up was 37 (range 6-126) months. For the entire cohort, the 5-year disease-free survival (DFS) and overall survival (OS) were 54.3% and 63.6%, respectively. The 5-year DFS rates for lymphovascular space invasion (LVSI) -positive and -negative patients were 41.6% and 88.3%, respectively (P < 0.001). The 5-year OS rates for LVSI-positive and -negative patients were 54.7% and 88.3%, respectively (P = 0.001). Positive LVSI status was identified as the independent prognostic factor for decreased DFS and OS (hazard ratio [HR] 5.5, 95% confidence interval [CI] 1.65-18.86; P = 0.006 versus HR 4.4, 95% CI 1.33-14.58; P = 0.013, respectively). Conclusion LVSI seems to be an independent prognostic factor for decreased DFS and OS in G3EEC patients.