Protective effect of caffeic acid phenethyl ester (CAPE) on myocardial ischemia-reperfusion-induced apoptotic cell death

Parlakpinar H., SAHNA E., Acet A., MIZRAK B., POLAT A.

TOXICOLOGY, cilt.209, sa.1, ss.1-14, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 209 Sayı: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.tox.2004.10.017
  • Dergi Adı: TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-14
  • Anahtar Kelimeler: apoptosis, caffeic acid phenethyl ester (CAPE), reactive oxygen radicals, rat, OXYGEN-FREE-RADICALS, MYOCYTE APOPTOSIS, NITRIC-OXIDE, INHIBITION, HEART, INJURY, INFARCTION, REDUCTION, ISCHEMIA/REPERFUSION, NEPHROTOXICITY
  • İnönü Üniversitesi Adresli: Evet

Özet

Occlusion of coronary artery causes cardiomyocyte dysfunction. Reperfusion relieves ischemia by providing cells with metabolites and oxygen, thereby preventing extensive tissue damage. Although reperfusion salvages the myocardium, it also initiates a series of events including myocardial apoptosis and necrosis.