Protective effect of caffeic acid phenethyl ester (CAPE) on myocardial ischemia-reperfusion-induced apoptotic cell death

Parlakpinar H. , SAHNA E., Acet A. , MIZRAK B., POLAT A.

TOXICOLOGY, cilt.209, ss.1-14, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 209 Konu: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.tox.2004.10.017
  • Dergi Adı: TOXICOLOGY
  • Sayfa Sayıları: ss.1-14


Occlusion of coronary artery causes cardiomyocyte dysfunction. Reperfusion relieves ischemia by providing cells with metabolites and oxygen, thereby preventing extensive tissue damage. Although reperfusion salvages the myocardium, it also initiates a series of events including myocardial apoptosis and necrosis.