Protective effect of caffeic acid phenethyl ester (CAPE) on myocardial ischemia-reperfusion-induced apoptotic cell death


Parlakpinar H. , SAHNA E., Acet A. , MIZRAK B., POLAT A.

TOXICOLOGY, cilt.209, ss.1-14, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 209 Konu: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.tox.2004.10.017
  • Dergi Adı: TOXICOLOGY
  • Sayfa Sayıları: ss.1-14

Özet

Occlusion of coronary artery causes cardiomyocyte dysfunction. Reperfusion relieves ischemia by providing cells with metabolites and oxygen, thereby preventing extensive tissue damage. Although reperfusion salvages the myocardium, it also initiates a series of events including myocardial apoptosis and necrosis.