Cytotoxic effects of coumarin substituted benzimidazolium salts against human prostate and ovarian cancer cells
JOURNAL OF CHEMICAL SCIENCES, cilt.131, sa.8, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 131 Sayı: 8
- Basım Tarihi: 2019
- Doi Numarası: 10.1007/s12039-019-1647-0
- Dergi Adı: JOURNAL OF CHEMICAL SCIENCES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Benzimidazole, benzimidazolium salt, coumarin, cytotoxicity, BIOLOGICAL EVALUATION, INHIBITORS SYNTHESIS, CARBONIC-ANHYDRASE, ANTITUMOR-ACTIVITY, ANTICANCER AGENTS, MOLECULAR DOCKING, HYBRIDS, IMIDAZOLIUM, DERIVATIVES, DESIGN
- İnönü Üniversitesi Adresli: Evet
Özet
Coumarin and benzimidazole derivatives have individual biological activities including anticancer. In this study, we aimed to synthesize coumarin-benzimidazole hybrids in order to investigate their anticancer properties. For this purpose, six 6-substituted-4-chloromethylene coumarin derivatives were synthesized. Sixteen coumarin substituted benzimidazolium chlorides were synthesized by the reaction of 4-chloromethylene coumarin and N-benzylbenzimidazole derivatives. All of the synthesized compounds were characterized by 1H and 13C NMR, IR spectroscopic techniques and elemental analyses. Cytotoxicities of all compounds were tested by [ 3-(4,5-dimethylthiazole)-2-yl]-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay against human prostate (PC-3) and ovarian (A2780) cancer cells. All compounds performed significant cytotoxicities at 100 mu Magainst both cancer cell lines. Moreover, some compounds performed significant activities at 1 mu M against both cancer cell lines and the obtained results suggest that this type of compounds are promising candidates for the treatment of human prostate and ovarian cancers.