Catechol-bearing imidazolium and benzimidazolium chlorides as promising antimicrobial agents
ARCHIV DER PHARMAZIE, cilt.353, sa.6, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 353 Sayı: 6
- Basım Tarihi: 2020
- Doi Numarası: 10.1002/ardp.202000013
- Dergi Adı: ARCHIV DER PHARMAZIE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chimica, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database, Index Chemicus (IC)
- Anahtar Kelimeler: antibacterial, antifungal, benzimidazolium, catechol, imidazolium, INHIBITORY PROPERTIES, CYTOTOXIC ACTIVITY, ANTITUMOR-ACTIVITY, ANTIBACTERIAL, COMPLEXES, SALTS, DERIVATIVES, DESIGN
- İnönü Üniversitesi Adresli: Evet
Özet
Catechol-containing imidazolium (four) and benzimidazolium chlorides (eight) were synthesized to evaluate their antimicrobial properties. All the compounds were fully characterized using H-1 and C-13 nuclear magnetic resonance, liquid chromatography-mass spectrometry, infrared spectroscopic methods, and elemental analyses. Antimicrobial activities of the compounds were tested against the bacteria Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Enterococcus faecalis, and the fungal strains Candida albicans and Candida glabrata, and promising results were achieved. The two most important benzyl-substituted benzimidazolium chlorides, 3l and 3k, showed comparable activity to vancomycin against MRSA.