Catechol-bearing imidazolium and benzimidazolium chlorides as promising antimicrobial agents

Karatas M. O. , GÜNAL S. , Mansur A., ALICI B. , ÖZDEMİR İ.

ARCHIV DER PHARMAZIE, cilt.353, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 353 Konu: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/ardp.202000013


Catechol-containing imidazolium (four) and benzimidazolium chlorides (eight) were synthesized to evaluate their antimicrobial properties. All the compounds were fully characterized using H-1 and C-13 nuclear magnetic resonance, liquid chromatography-mass spectrometry, infrared spectroscopic methods, and elemental analyses. Antimicrobial activities of the compounds were tested against the bacteria Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Enterococcus faecalis, and the fungal strains Candida albicans and Candida glabrata, and promising results were achieved. The two most important benzyl-substituted benzimidazolium chlorides, 3l and 3k, showed comparable activity to vancomycin against MRSA.