Ghrelin prevents the development of dermal fibrosis in bleomycin-induced scleroderma


Koca S. S. , Ozgen M., Sarikaya M., Dagli F., Ustundag B., Isik A.

CLINICAL AND EXPERIMENTAL DERMATOLOGY, cilt.39, ss.176-181, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 39 Konu: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1111/ced.12195
  • Dergi Adı: CLINICAL AND EXPERIMENTAL DERMATOLOGY
  • Sayfa Sayıları: ss.176-181

Özet

BackgroundScleroderma is a chronic inflammatory disease characterized by widespread fibrosis of the skin and the internal organs. Ghrelin is a polypeptide hormone produced by various tissues and inflammatory cells. In experimental studies, ghrelin has been shown to have anti-inflammatory and antioxidant effects, in addition to its metabolic actions.