Is Serum Progranulin Level a Biomarker in Autism and Cognitive Development Disorders?

ÖZGERİŞ F. B., KURT N., UCUZ İ., Yilmaz K. K., Keles M. S., Cayir A., ...Daha Fazla

EURASIAN JOURNAL OF MEDICINE, cilt.54, sa.1, ss.50-53, 2022 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5152/eurasianjmed.2022.21292
  • Dergi Adı: EURASIAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.50-53
  • Anahtar Kelimeler: Autism spectrum disorders, cognitive developmental delay, progranulin, FRONTOTEMPORAL DEMENTIA, LYSOSOMAL DYSFUNCTION, HOST-DEFENSE, IMMUNITY, INFLAMMATION, ELASTASE, CHILDREN, BRAIN
  • İnönü Üniversitesi Adresli: Evet

Özet

Objective: Cognitive developmental delay is a picture of the group of early-onset chronic diseases that affect 1.5-10% of children. Autism spectrum disorders are neurodevelopmental diseases with a genetic basis and abnormal brain development, characterized by disorders in areas that make up interpersonal relationships, such as communication, social cognition, and processing of emotional signals. Immune system dysfunction is thought to play a role in the pathogenesis of some neurological disorders, including autism. Progranulin is thought to be a regulator of the innate immune response. The purpose of this study was to look at plasma levels of progranulin, an anti-inflammatory neurotrophic factor, in children with autism spectrum disorder and cognitive developmental delay.