Protective effects of colchicine in an experimental model of necrotizing enterocolitis in neonatal rats

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YURTTUTAN S., Ozdemir R., CANPOLAT F. E., ONCEL M. Y., UYSAL B., UNVERDI H. G., ...More

JOURNAL OF SURGICAL RESEARCH, vol.183, no.1, pp.156-162, 2013 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 183 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1016/j.jss.2013.01.002
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.156-162
  • Inonu University Affiliated: Yes

Abstract

Background: The pathophysiology of necrotizing enterocolitis (NEC) includes the massive production of endogenous cytokines with exaggerated activation of inflammatory pathways. Colchicine has been used as an anti-inflammatory agent. The aim of this study was to investigate the possible beneficial effects of colchicine in a neonatal rat model of NEC.