Potential for cytokine and product manipulation to improve the results of autologous stem cell transplantation for rheumatoid arthritis


Talmadge J., Singh R., Ino K., Ageitos A., Buyukberber S.

JOURNAL OF RHEUMATOLOGY, cilt.28, ss.32-38, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 28
  • Basım Tarihi: 2001
  • Dergi Adı: JOURNAL OF RHEUMATOLOGY
  • Sayfa Sayıları: ss.32-38

Özet

The eradication of autoreactive T cells by high dose therapy and stein cell transplantation and the resultant alterations in the immunologic network, thymic reeducation, and peripheral tolerance provide treatment mechanisms for autoimmune and inflammatory diseases. One outcome of autologous stein cell transplantation is a significant decrease in the CD4:CD8 ratio due to a loss in CD4+ cells and a depression in T cell function. Mechanistically, the loss of T cell function is associated with an increased frequency of circulating monocytes, their expression of Fas ligand (FasL). and it high frequency of apoptotic CD4+ T cells. This suggests that activated Fas+ CD4+ lymphocytes interact with FasL+ monocytes, resulting in apoptosis, preferential deletion of CD4+ T cells, an inversion in the CD4:CD8 ratio, and depressed T cell function. These observations suggest the potential for immune regulation using stem cell manipulation or posttransplant cytokine administration its therapeutic strategies for autoimmune/inflammatory diseases.