Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage

Esrefoglu M., Cetin A., Taslidere E., Elbe H., Ates B., Tok O. E., ...More

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.118, no.6, pp.347-354, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 118 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.4149/bll_2017_066
  • Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.347-354
  • Keywords: antioxidant, melatonin, quercetin, liver, ACID PHENETHYL ESTER, CARBON-TETRACHLORIDE, INDUCED HEPATOTOXICITY, LIPID-PEROXIDATION, LIVER-DAMAGE, CAFFEIC ACID, NONALCOHOLIC STEATOHEPATITIS, SUPEROXIDE-DISMUTASE, MECHANISMS, INJURY
  • Inonu University Affiliated: Yes

Abstract

BACKGROUND: Non-alcoholic steatohepatitis, a cause of cirrhosis, is characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis. The aim of the present study was to investigate the effects of melatonin and quercetin on CCl4-induced steatosis characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis.