Molsidomine Prevents Cisplatin-induced Hepatotoxicity


BENTLİ R. , PARLAKPINAR H. , POLAT A. , ŞAMDANCI E. , SARIHAN M. E. , SAGIR M.

ARCHIVES OF MEDICAL RESEARCH, cilt.44, ss.521-528, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 44 Konu: 7
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.arcmed.2013.09.013
  • Dergi Adı: ARCHIVES OF MEDICAL RESEARCH
  • Sayfa Sayıları: ss.521-528

Özet

Background and Aims. Despite its beneficial effects, cisplatin has considerable nephrotoxic, ototoxic, neurotoxic and hepatotoxic side effects. It has been documented that reactive oxygen radical species are involved with the pathophysiology of cisplatin-induced hepatotoxicity. Molsidomine (MOL) can exert antioxidant and anti-inflammatory effects. Therefore, the current study was planned to determine the effects of cisplatin on the liver oxidant/antioxidant system and the possible protective effects of (MOL) on liver toxicity.