Molsidomine Prevents Cisplatin-induced Hepatotoxicity

BENTLİ R., PARLAKPINAR H., POLAT A., ŞAMDANCI E., SARIHAN M. E., SAGIR M.

ARCHIVES OF MEDICAL RESEARCH, cilt.44, sa.7, ss.521-528, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 7
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.arcmed.2013.09.013
  • Dergi Adı: ARCHIVES OF MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.521-528
  • Anahtar Kelimeler: Cisplatin, Molsidomine, Liver, Oxidative stress, OXIDE DONOR MOLSIDOMINE, ISCHEMIA-REPERFUSION INJURY, NITRIC-OXIDE, INDUCED NEPHROTOXICITY, HEPATOCYTE APOPTOSIS, MYOCARDIAL-ISCHEMIA, OXIDATIVE STRESS, LIVER-DAMAGE, MELATONIN, PROTECTS
  • İnönü Üniversitesi Adresli: Evet

Özet

Background and Aims. Despite its beneficial effects, cisplatin has considerable nephrotoxic, ototoxic, neurotoxic and hepatotoxic side effects. It has been documented that reactive oxygen radical species are involved with the pathophysiology of cisplatin-induced hepatotoxicity. Molsidomine (MOL) can exert antioxidant and anti-inflammatory effects. Therefore, the current study was planned to determine the effects of cisplatin on the liver oxidant/antioxidant system and the possible protective effects of (MOL) on liver toxicity.