Synthesis and antibacterial activities of new bis-benzimidazoles

KÜÇÜKBAY H., Durmaz R., Okuyucu N., Gunal S., Kazaz C.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, vol.54, no.1, pp.64-68, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1055/s-0031-1296938
  • Journal Name: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.64-68
  • Keywords: bis-benzimidazole derivatives, antibacterial activity, in vitro studies, synthesis, ANTIMICROBIAL ACTIVITY, DERIVATIVES, BENZOTHIAZOLE, IMIDAZOLE, AGENTS
  • Inonu University Affiliated: Yes

Abstract

Twenty bis-benzimidazole derivatives were synthesised by the reaction of benzimidazole with appropriate alkyl halides. The compounds synthesised were identified by H-1, C-13-NMR, FT-IR and micro analysis. All compounds studied in this work were screened for their in vitro antibacterial activity against standard strains; Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853). Ten of the compounds were found effective to inhibit the growth of gram-positive bacteria (E. faecalis and S. aureus) at MIC (minimal inhibitory concentration) values between 50-400 mug/ml. Two of the compounds showed MIC values of 200 mug/ml against gram-negative bacteria (E. coli and P aeruginosa).