Synthesis and antibacterial activities of new bis-benzimidazoles

KÜÇÜKBAY H., Durmaz R., Okuyucu N., Gunal S., Kazaz C.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, cilt.54, sa.1, ss.64-68, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1055/s-0031-1296938
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.64-68
  • Anahtar Kelimeler: bis-benzimidazole derivatives, antibacterial activity, in vitro studies, synthesis, ANTIMICROBIAL ACTIVITY, DERIVATIVES, BENZOTHIAZOLE, IMIDAZOLE, AGENTS
  • İnönü Üniversitesi Adresli: Evet

Özet

Twenty bis-benzimidazole derivatives were synthesised by the reaction of benzimidazole with appropriate alkyl halides. The compounds synthesised were identified by H-1, C-13-NMR, FT-IR and micro analysis. All compounds studied in this work were screened for their in vitro antibacterial activity against standard strains; Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853). Ten of the compounds were found effective to inhibit the growth of gram-positive bacteria (E. faecalis and S. aureus) at MIC (minimal inhibitory concentration) values between 50-400 mug/ml. Two of the compounds showed MIC values of 200 mug/ml against gram-negative bacteria (E. coli and P aeruginosa).