Protective effects of L-carnitine on myoglobinuric acute renal failure in rats

Aydogdu, NURETTİN; ATMACA, G; YALCIN, O; TASKIRAN, R; TASTEKIN, E; KAYMAK, K

doi:10.1111/j.1440-1681.2006.04336.x

Protective effects of L-carnitine on myoglobinuric acute renal failure in rats

Atıf İçin Kopyala

Aydogdu N., ATMACA G., YALCIN O., TASKIRAN R., TASTEKIN E., KAYMAK K.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, cilt.33, ss.119-124, 2006 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 33
Basım Tarihi: 2006
Doi Numarası: 10.1111/j.1440-1681.2006.04336.x
Dergi Adı: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.119-124
İnönü Üniversitesi Adresli: Hayır

Özet

1. Muscle injury (rhabdomyolysis) is one of the causes of acute renal failure (ARF). Iron, free radicals and nitric oxide (NO) play a critical role in the pathogenesis of glycerol-induced myoglobinuric ARF. L-Carnitine is an anti-oxidant and prevents the accumulation of end-products of lipid peroxidation. Therefore, the aim of the present study was to investigate the effects of L-carnitine on myoglobinuric ARF induced by intramuscular (i.m.) hypertonic glycerol injection.