Protective effects of L-carnitine on myoglobinuric acute renal failure in rats


Aydogdu N. , ATMACA G., YALCIN O., TASKIRAN R., TASTEKIN E., KAYMAK K.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, cilt.33, ss.119-124, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 33
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1440-1681.2006.04336.x
  • Dergi Adı: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Sayfa Sayıları: ss.119-124

Özet

1. Muscle injury (rhabdomyolysis) is one of the causes of acute renal failure (ARF). Iron, free radicals and nitric oxide (NO) play a critical role in the pathogenesis of glycerol-induced myoglobinuric ARF. L-Carnitine is an anti-oxidant and prevents the accumulation of end-products of lipid peroxidation. Therefore, the aim of the present study was to investigate the effects of L-carnitine on myoglobinuric ARF induced by intramuscular (i.m.) hypertonic glycerol injection.