The Ameliorate Effects of Nerolidol on Thioacetamide-induced Oxidative Damage in Heart and Kidney Tissue

BAŞAK TÜRKMEN N., YÜCE H., TAŞLIDERE A., ŞAHİN Y., ÇİFTÇİ O.

Turk J Pharm Sci, vol.19, no.1, pp.1-8, 2022 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.4274/tjps.galenos.2021.30806
  • Journal Name: Turk J Pharm Sci
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1-8
  • Keywords: Nerolidol, thioacetamide, lipid peroxidation, nephrotoxicity, cardiotoxicity, ESSENTIAL OIL, CHEMICAL-COMPOSITION, ANTIOXIDANT, INJURY, NEPHROTOXICITY, ACTIVATION, STRESS, LEAVES
  • Inonu University Affiliated: Yes

Abstract

Objectives: Thioacetamide (TAA) is an organosulfur, white crystalline compound having liver injury. However, it shows toxic effects on many organs. The reverts the oxidative stress created by TAA on the heart and kidney, and decreased lipid peroxide peroxidation back with antioxidant-properties nerolidol (NRL). This study hypothesized that NRL treatment a potential ameliorate nephrotoxicity and cardiotoxicity caused by TAA.