Comparison of the effects of PRP and hyaluronic acid in promoting peripheral nerve regeneration An experimental study with vascular conduit model in rats'

FIRAT C., Aytekin A. H., DURAK M. A., Geyik Y., Erbatur S., Dogan M., ...More

ANNALI ITALIANI DI CHIRURGIA, vol.87, no.4, pp.362-374, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 87 Issue: 4
  • Publication Date: 2016
  • Journal Name: ANNALI ITALIANI DI CHIRURGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.362-374
  • Inonu University Affiliated: Yes

Abstract

AIM: Peripheral nerve defects generally occur due to mechanical, chemical, thermal and pathologic causes and the reconstruction is still a challenging problem. In the present study, we aimed to compare the effects of platelet rich plasma (PRP) that has high levels of growth factors and hyaluronic acid (HA) that is known to have positive effects on nerve regeneration by decreasing scar formation in a rat model where they were injected through allogeneic aorta graft in peripheral nerve defects using histopathologic and functional methods.