Synthesis, characterization and antimicrobial activities of novel silver(I) complexes with coumarin substituted N-heterocyclic carbene ligands

KARATAŞ M. O., Olgundeniz B., GÜNAL S., ÖZDEMİR İ., ALICI B., Cetinkaya E.

BIOORGANIC & MEDICINAL CHEMISTRY, cilt.24, sa.4, ss.643-650, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.bmc.2015.12.032
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.643-650
  • Anahtar Kelimeler: Antibacterial, Antifungal, Coumarin, Carbene, Silver, RESISTANT PSEUDOMONAS, CRYSTAL-STRUCTURES, SULFADIAZINE, DERIVATIVES, ANTICANCER, PALLADIUM, GYRASE, BURNS
  • İnönü Üniversitesi Adresli: Evet

Özet

Eight new coumarin substituted silver(I) N-heterocyclic carbene (NHC) complexes were synthesized by the interaction of the corresponding imidazolium or benzimidazolium chlorides and Ag2O in dichloromethane at room temperature. Structures of these complexes were established on the basis of elemental analysis, H-1 NMR, C-13 NMR, IR and mass spectroscopic techniques. The antimicrobial activities of carbene precursors and silver NHC complexes were tested against standard strains: Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and the fungi Candida albicans and Candida tropicalis. Results showed that all the compounds inhibited the growth of the all bacteria and fungi strains and some complexes performed good activities against different microorganisms. Among all the compounds, the most lipophilic complex bis[1-(4-methylene-6,8-dimethyl-2H-chromen-2-one)-3-(naphthalene-2-ylmethyl)benzimidazol-2-ylidene]silver(I) dichloro argentate (5e) was found out as the most active one. (c) 2015 Elsevier Ltd. All rights reserved.