The purpose of this in vitro study was to compare the shear bond strengths (SBS) of hybrid ceramic; Vita Enamic (VE), zirconia-reinforced lithium silicate ceramic; Vita Suprinity (VS), feldspathic ceramic; Vita TriLuxe forte (VT), and lithium disilicate ceramic; IPS e.max CAD (IPS). Eighty specimens were prepared from four different CAD-CAD ceramic materials. The CAD-CAM ceramic specimens were randomly divided into two subgroups according to acid types: phosphoric (P) acid and hydrofluoric (HF) acid. Resin cement (Panavia V5; Kuraray, Japan) was applied using a 3 x 3-millimeter mold. All specimens were stored in distilled water at 37 degrees C for 24 hours. The SBS test was performed using a universal testing machine (0.5 mm/min). Two-way ANOVA was used to detect significant differences among the CAD-CAM ceramic materials and acid types. Subgroup analyses were conducted using Tukey HSD post-hoc test (p < 0.05). The lowest SBS value was seen in the VE group (4.5 +/- 2.2 MPa) for P acid etching. The highest SBS value was seen in the IPS group (19.5 +/- 8.3 MPa) for HF acid etching.