Platinum (II) N-heterocyclic carbene complexes: Synthesis, characterization and cytotoxic properties


KARACA E. Ö. , Ciftci O., ÖZDEMİR İ., Yakali G., Aygun M., GÜRBÜZ N., ...More

APPLIED ORGANOMETALLIC CHEMISTRY, vol.33, no.7, 2019 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 7
  • Publication Date: 2019
  • Doi Number: 10.1002/aoc.4851
  • Journal Name: APPLIED ORGANOMETALLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: antitumor activity, Imidazolidine-2-ylidene, N-heterocyclic carbene, platinum complexes, ELECTRON-RICH OLEFIN, IN-VITRO EVALUATION, ORGANOMETALLIC COMPLEXES, COORDINATION CHEMISTRY, ANTICANCER PROPERTIES, NUCLEOPHILIC-CARBENE, GOLD(I) COMPLEXES, METAL-COMPLEXES, LIGANDS, CISPLATIN

Abstract

Platinum (II) complexes bearing N-heterocyclic carbene (NHC) ligands have been widely used in catalytic chemistry, but there are very few reports of biological properties of this type of complexes. A series of [PtCl2(NHC)(PEt3)] complexes were synthesized. The structures of all compounds were characterized by H-1-NMR, C-13-NMR, IR and elemental analysis techniques, which supported the proposed structures. The single crystal structures of complexes 1a and 1e were determined. The title complexes show slightly distorted square-planar coordination around the platinum (II) metal center. The cytotoxic properties of the platinum (II)-NHC complexes have been assessed in various human cancer lines, including cisplatin-sensitive and resistant cells. IC50 values of these four complexes were determined by the MTS-based assay on three human cell lines-brain (SHSY5Y), colon (HTC116) and liver (HEP3B). These complexes have been highlighted cancer therapeutic agent with unique structures and functions.