Well-defined palladium N-heterocyclic carbene complexes bearing CF3 moiety: Synthesis, characterization, crystal structure, direct C4-arylation of 3,5-dimethylisoxazole and antioxidant activity

Kalçık A., Kaloğlu N., Keser S., Şahin Z. S., DEMİR DÜŞÜNCELİ S.

Journal of Organometallic Chemistry, cilt.1045, 2026 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1045
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1016/j.jorganchem.2025.123975
  • Dergi Adı: Journal of Organometallic Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex
  • Anahtar Kelimeler: Antioxidant activity, Direct C4-arylation, Isoxazole, N-Heterocyclic carbene, Palladium complex
  • İnönü Üniversitesi Adresli: Evet

Özet

A series of palladium N-heterocyclic carbene (NHC) complexes including trans-[Pd(NHC)Br2L] (L = C5H5N, 3-ClC5H4N, and N-methylimidazole) and [Pd(NHC)2Br2] have been prepared from {1-(benzyl)-3- (3,5-(bis(trifluoromethyl)benzyl)benzimidazolium bromide}. The structures of these new compounds were confirmed by NMR, FT-IR, and elemental analyses. The crystal structures of the dibromo- [1-(benzyl)-3- (3,5-(bis(trifluoromethyl)benzyl)benzimidazole-2-ylidene]-(pyridine)-palladium(II) and dibromo- [1-(benzyl)-3- (3,5-(bis(trifluoromethyl)benzyl)benzimidazole-2-ylidene]-(N-methylimidazole)-palladium(II) were determined by single-crystal X-ray diffraction. Palladium complexes were developed as efficient pre-catalysts for direct C4-arylation of 3,5-dimethylisoxazole and aryl bromides. Biological efficiency of trans-[Pd(NHC)Br2L]was evaluated by antioxidant activities like ABTS, OH and DPPH radical scavenging activity assays.