Neurosteroids and cognitive functions in depressed women

Kartalci Ş., EŞEL E., DEMİREL-ÖZSOY S., Kula M., Turan T.

KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY, cilt.18, sa.1, ss.9-21, 2008 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2008
  • Dergi Adı: KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.9-21
  • Anahtar Kelimeler: cognitive functions, dehydroepiandrosterone sulfate (DHEAS), dexamethasone suppression test (DST), hypothalamic-pituitary-adrenal (HPA) axis, major depression, neurosteroids, PLASMA DEHYDROEPIANDROSTERONE-SULFATE, MAJOR DEPRESSION, ANTIDEPRESSANT TREATMENT, NEUROACTIVE STEROIDS, HORMONE STIMULATION, PREFRONTAL CORTEX, ADRENAL ANDROGENS, CORTISOL, MEMORY, FLUOXETINE
  • İnönü Üniversitesi Adresli: Evet

Özet

Objective: Dehydroepiandrosterone (DHEA) and its sulfate ester dehydroepiandrosterone sulfate (DHEAS) are known to be neuroactive steroids and are proposed to have GABA antagonistic properties. The aim of this study was to investigate whether DHEAS is related to the pathophysiology of depression by examining alterations in serum DHEAS levels and its regulatory factors by the dexamethasone suppression test (DST), and whether there is any relationship between these alterations and cognitive functions in depression. We also investigated if any alteration takes place in these hormonal variables with antidepressant treatment.