A Neuromyelitis Optica Spectrum Disorder Case Presenting with the Syndrome of Inappropriate Antidiuretic Hormone Secretion

Algul F. E., KAMIŞLI S.

GAZI MEDICAL JOURNAL, cilt.30, sa.1, ss.84-87, 2019 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.12996/gmj.2019.24
  • Dergi Adı: GAZI MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.84-87
  • İnönü Üniversitesi Adresli: Evet

Özet

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is one of the most important causes of hyponatremia. SIADH has been associated many clinical states, syndromes and many other central nervous disorders. Neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorders (NMOSD) are also a few of these. NMO is a demyelinating autoimmune disorder affected the brainstem and hypothalamus where express high levels of aquaporin-4 (AQP-4) protein. Although detecting antiaquaporin-4 antibody positive is important for the diagnosis, some NMO and NMOSD patients show seronegative AQP-4 antibody results. We report a seronegative NMO spectrum disorder case presenting with the SIADH.