Fulminant hepatitis A infection in second trimester of pregnancy requiring living-donor liver transplantation

Simsek Y., IŞIK B. , KARAER A. , Celik O., KUTLU R. , Aydin N. E. , ...Daha Fazla

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, cilt.38, ss.745-748, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 38 Konu: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1111/j.1447-0756.2011.01757.x
  • Sayfa Sayıları: ss.745-748


We present an 18-year-old pregnant woman who was referred to our emergency clinic as a case of acute hepatic failure and hepatic encephalopathy. Laboratory tests showed abnormal liver function tests and serological workup was consistent with acute hepatitis A infection. Ultrasonography revealed a single live fetus with fetal biometry compatible with 18 gestational weeks. The patient underwent a highly urgent liver transplantation using a right lobe graft from her husband. Histological examination of the explanted liver showed acute, lymphocyte-rich, diffuse necrotizing hepatitis, consistent with acute necrotizing hepatitis A. After the operation her allograft function gradually recovered. Her follow-up obstetrics ultrasound revealed a male fetus with severely decreased amniotic fluid. The patient was informed about the poor prognosis of her pregnancy and the pregnancy was terminated by vaginal misoprostol induction. She has maintained a good general condition and liver function for 4 months postoperatively, up to the present time.