Induced angiogenesis with intramedullary direct current: experimental research

Inan M., Alat I., Gurses I., Kekilli E., Kutlu R., Eskin A., ...More

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, vol.288, no.2, 2005 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 288 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1152/ajpheart.01222.2003
  • Journal Indexes: Science Citation Index Expanded, Scopus


The purpose of this study was to evaluate angiogenesis after the use of intramedullary direct electrical current in rabbit tibia. Thirty-two New Zealand rabbits were divided into four groups: group 1, false electrode group; group 2, hole group; group 3, control group; and group 4, intramedullary electrical stimulation group. One-half of the rabbits in each group were evaluated angiographically, pathologically, and scintigraphically on day 7, and the rest were evaluated on day 21. Results proved that electrical stimulation was not capable of the induction of angiogenesis in the subjects killed on day 7 and day 21. Furthermore, we found some fibrotic changes secondary to electrical stimulation on day 7 ( P = 0.04) and day 21 ( P = 0.01). However, an increase in new capillary vessels occurred in the false electrode group ( P = 0.02). We found no useful effect of electrical stimulation in our study, a finding that is possibly due to our use of a method previously undocumented in the literature. We believe that this study can be the new baseline for further studies into the stimulation or inhibition of angiogenesis using intramedullary wire with or without electrical stimulation.