The impact of COVID-19 pandemic on nosocomial multidrug-resistant bacterial bloodstream infections and antibiotic consumption in a tertiary care hospital


METAN G., DEMİR ÇUHA M., HAZIROLAN G., TELLİ DİZMAN G., TANRİVERDİ E. S. , OTLU B., ...More

GMS HYGIENE AND INFECTION CONTROL, vol.17, 2022 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 17
  • Publication Date: 2022
  • Doi Number: 10.3205/dgkh000418
  • Journal Name: GMS HYGIENE AND INFECTION CONTROL
  • Journal Indexes: Emerging Sources Citation Index
  • Keywords: COVID-19, SARS-CoV-2, antibacterial resistance, bacteremia, antibiotic consumption, ACINETOBACTER-BAUMANNII

Abstract

We investigated the change in the epidemiology of nosocomial blood-stream infections (BSIs) caused by multidrug-resistant bacteria during Coronavirus Disease (COVID-19) and antibiotic consumption rates at a pandemic hospital and at the Oncology Hospital which operated as COVID-19-free on the same university campus. Significant increases in the infection density rate (IDRs) of BSIs caused by carbapenem-resistant Acinetobacter baumannii (CRAB) and ampicillin-resistant Enterococcus faecium (ARE) were detected at the pandemic hospital, whereas car-bapenem-resistant Klebsiella pneumoniae BSIs were increased at the non-pandemic Oncology Hospital. Pulsed field gel electrophoresis showed a polyclonal outbreak of CRAB in COVID-19 intensive care units. Antibiotic consumption rates were increased for almost all antibiotics, and was most significant for meropenem at both of the hospitals. In-creased IDRs of CRAB and ARE BSIs as well as an increased consump-tion rate of broad-spectrum antibiotics emphasize the importance of a multimodal infection prevention strategy combined with an active anti-biotic stewardship program.