Phytochemical compounds and antiradical, antimicrobial, and cytotoxic activities of the extracts from Hypericum scabrum L. Flowers
NATURAL PRODUCT RESEARCH, vol.34, no.5, pp.714-719, 2020 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 34 Issue: 5
- Publication Date: 2020
- Doi Number: 10.1080/14786419.2018.1493735
- Journal Name: NATURAL PRODUCT RESEARCH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, CAB Abstracts, CINAHL, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
- Page Numbers: pp.714-719
- Keywords: H, scabrum, antiradical, phytochemical, cytotoxic, antimicrobial, ANTIBACTERIAL ACTIVITY, ESSENTIAL OILS, ANTIOXIDANT, PERFORATUM, SCABROIDES, SEED, LEAF
- Inonu University Affiliated: Yes
Abstract
Hypericum scabrum L. has been widely used in traditional medicine for the treatment of many diseases just as the other Hypericum species. In the present study, the antiradical, antimicrobial and cytotoxic activities of water and ethanol extracts of H. scabrum flowers were investigated. Their phytochemical contents and composition were also determined. The water and ethanol extracts are better scavenged ABTS (97.89 and 98.99%) and OH radicals (96.36 and 97.33%); the water extract is better scavenged DPPH radicals (91.66%) than the standard antioxidant BHA (94.33, 85.19, 90.16%, respectively). Flowers of H. scabrum contain flavonoids, phenolic acids, vitamins and phytosterols, dominated by catechin, vanillic acid, vitamin K and ergosterol. The extracts exhibit a strong cytotoxic activity against MCF-7, HCT-116, and LNCaP cancer cell lines. It is found that their antimicrobial activities are higher than the standard antibiotics. These results indicate that H. scabrum flowers have potent antiradical, antimicrobial and cytotoxic activities.