Novel ruthenium(II) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activities

Jawhari A. H., Amri N., Mukhrish Y. E., Gatri R., ÖZDEMİR İ., GÜRBÜZ N., ...Daha Fazla

Main Group Metal Chemistry, cilt.46, sa.1, 2023 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1515/mgmc-2023-0008
  • Dergi Adı: Main Group Metal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, Metadex, Directory of Open Access Journals, Civil Engineering Abstracts
  • Anahtar Kelimeler: benzimidazolium salts, biological activity, HCT-116, HepG-2, ruthenium complexes, silver complexes
  • İnönü Üniversitesi Adresli: Evet

Özet

A series of ruthenium(II) complexes with N-heterocyclic carbene (NHC) ligands of the general type (arene) (NHC)Ru(II)X2 (where X = halide) (3a–3d) were synthesized and characterized in order to compare their antibacterial activities with benzimidazolium salts 2. Our comparison revealed that ruthenium(II) NHC complexes 3 were more active than benzimidazolium salts 2. Furthermore, the two complexes 3b and 3d had a potent inhibitory effect against acetylcholinesterase with an IC50 of 4.52 and 4.04 g·mL−1 and against tyrosinase with an IC50 of 20.77 and 25.84 g·mL−1, respectively. In addition, screening of benzimidazolium salts (2a–2d) and their ruthenium(II) complexes (3a–3d) against colon carcinoma cell lines (HCT-116) and hepatocellular carcinoma cell lines (HepG-2) were studied. The obtained results revealed that complex 3a is the most active against vinblastines.