Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer


Gecit I. , Aslan M., Gunes M., Pirincci N., Esen R., Demir H., ...Daha Fazla

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, cilt.138, ss.739-743, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 138 Konu: 5
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s00432-011-1136-4
  • Dergi Adı: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Sayfa Sayıları: ss.739-743

Özet

Prolidase is a member of the matrix metalloproteinase family. It plays a major role in collagen turnover, matrix remodeling and cell growth. Nitric oxide (NO) regulates many processes such as collagen synthesis and matrix remodeling. Thus, NO may augment angiogenesis, tumor invasion, and metastasis. The aim of this study was to investigate total antioxidant status (TAS), malondialdehyde (MDA) and NO levels in patients with bladder cancer and to determine their relationship with prolidase activity.