Effect of permeability enhancers on paracellular permeability of acyclovir


Ates M. , KAYNAK M. S. , ŞAHİN S.

JOURNAL OF PHARMACY AND PHARMACOLOGY, cilt.68, ss.781-790, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 68 Konu: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1111/jphp.12551
  • Dergi Adı: JOURNAL OF PHARMACY AND PHARMACOLOGY
  • Sayfa Sayıları: ss.781-790

Özet

Objectives According to Biopharmaceutics Classification System (BCS), acyclovir is a class III (high solubility, low permeability) compound, and it is transported through paracellular route by passive diffusion. The aim of this study was to investigate the effect of various pharmaceutical excipients on the intestinal permeability of acyclovir.