Advancing Pulmonary Embolism Detection with Integrated Deep Learning Architectures


BİRET C. B., GÜRBÜZ Ş., Akbal E., Baygin M., Ekingen E., DERYA S., ...Daha Fazla

Journal of Imaging Informatics in Medicine, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/s10278-025-01506-6
  • Dergi Adı: Journal of Imaging Informatics in Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Deep feature engineering, HybridNeXt, INCA, Pulmonary embolism detection, Self-organized model
  • İnönü Üniversitesi Adresli: Evet

Özet

The main aim of this study is to introduce a new hybrid deep learning model for biomedical image classification. We propose a novel convolutional neural network (CNN), named HybridNeXt, for detecting pulmonary embolism (PE) from computed tomography (CT) images. To evaluate the HybridNeXt model, we created a new dataset consisting of two classes: (1) PE and (2) control. The HybridNeXt architecture combines different advanced CNN blocks, including MobileNet, ResNet, ConvNeXt, and Swin Transformer. We specifically designed this model to combine the strengths of these well-known CNNs. The architecture also includes stem, downsampling, and output stages. By adjusting the parameters, we developed a lightweight version of HybridNeXt, suitable for clinical use. To further improve the classification performance and demonstrate transfer learning capability, we proposed a deep feature engineering (DFE) method using a multilevel discrete wavelet transform (MDWT). This DFE model has three main phases: (i) feature extraction from raw images and wavelet bands, (ii) feature selection using iterative neighborhood component analysis (INCA), and (iii) classification using a k-nearest neighbors (kNN) classifier. We first trained HybridNeXt on the training images, creating a pretrained HybridNeXt model. Then, using this pretrained model, we extracted features and applied the proposed DFE method for classification. The HybridNeXt model achieved a test accuracy of 90.14%, while our DFE model improved accuracy to 96.35%. Overall, the results confirm that our HybridNeXt architecture is highly accurate and effective for biomedical image classification. The presented HybridNeXt and HybridNeXt-based DFE methods can potentially be applied to other image classification tasks.