Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats

ERDOĞAN M. A. , Yalcin A.

ARCHIVES OF MEDICAL SCIENCE, cilt.16, ss.205-211, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 16 Konu: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5114/aoms.2018.80002
  • Dergi Adı: ARCHIVES OF MEDICAL SCIENCE
  • Sayfa Sayıları: ss.205-211

Özet

Introduction: Methotrexate (MTX) causes hepatotoxicity by producing oxidative stress. Benfotiamine and irisin have protective effects against oxidative stress. The aim of this study was to investigate the changes in irisin activity in the liver as a result of toxicity produced by MTX and the protective role of benfotiamine in the hepatotoxicity.