Akademik Veri Yönetim Sistemi
International Journal of Clinical Practice, cilt.2026, sa.1, 2026 (SCI-Expanded, Scopus)
Background: Acute appendicitis is one of the most common surgical emergencies in childhood. Its clinical management poses particular challenges in younger age groups. Blood parameters and inflammatory scoring systems have recently been investigated as promising biomarkers for prognostic prediction. However, the number of studies addressing this issue in the pediatric population remains limited. Methods: This study was conducted retrospectively, and pediatric patients diagnosed with acute appendicitis were included. Hematological parameters (WBC, HGB, NEU%, LYM, and PLT), biochemical markers (ALB, CRP, and GLC), and inflammatory indices (NLR, LAR, HALP, SII, SIRI, and WAR) were analyzed. The findings were evaluated in relation to complications (perforation, abscess, and mesenteric inflammation), length of hospital stay, and appendiceal diameter measured by ultrasonography. ROC analyses were performed to assess prognostic factors. Results: The HALP score was found to be significantly higher in patients without perforation (p = 0.048). NEU%, NLR, and SII values were elevated in patients with abscess formation, whereas LYM, LAR, and HALP were higher in those without abscess (p < 0.05). HGB, ALB, and HALP levels were significantly higher in patients without mesenteric inflammation, indicating an inverse relationship with the severity of inflammation. No correlation was observed between blood parameters and length of hospital stay; however, a weak but significant positive correlation was found among WBC, HGB, NEU%, NLR, SII, SIRI, and appendiceal diameter. ROC analysis demonstrated that HGB and HTC had moderate discriminative ability for mesenteric inflammation (AUC = 0.70), whereas GLC, NLR, and SII showed strong discriminative performance for abscess prediction (AUC = 0.84, 0.88, 0.93). Conclusion: Our findings suggest that HALP, NLR, and SII may hold prognostic value in pediatric patients with appendicitis. However, these parameters alone are insufficient and should be interpreted in conjunction with clinical and imaging findings. Validation of the results in larger, multicenter studies is required.