Behcet's disease is a multisystem disorder. Intestinal involvement is common in patients from the Far East, but is rare among those from the Middle East. The most frequent area of involvement is the ileocecal region. Although intestinal perforations of Behcet's disease are most frequently seen in the cecum, perforations of the sigmoid and descending colon have also been reported in the literature. A 45-year-old man with Behcet's disease admitted to our hospital with abdominal pain and active lower gastrointestinal bleeding. A colonoscopic examination revealed multiple perforated ulcers in the descending colon. He was followed-up conservatively, and no surgical intervention was required. Descending-colon perforation is a rare complication of Behcet's disease. Our patient recovered with conservative medical treatment, without surgery. Therefore, this case suggests that medical treatment with close follow-up may be useful in the management of intestinal perforations in Behcet's disease.