Evaluation of Transcranial Magnetic Stimulation Efficiency in Major Depressive Disorder Patients: A Magnetic Resonance Spectroscopy Study

ERBAY M. F., Zayman E. P., GÖNENİR ERBAY L., ÜNAL S.

PSYCHIATRY INVESTIGATION, vol.16, no.10, pp.745-750, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 10
  • Publication Date: 2019
  • Doi Number: 10.30773/pi.2019.07.17.3
  • Journal Name: PSYCHIATRY INVESTIGATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.745-750
  • Keywords: Transcranial magnetic stimulation, Depression, Magnetic resonance spectroscopy, Brain metabolites, FRONTAL WHITE-MATTER, DORSOLATERAL PREFRONTAL CORTEX, ANTERIOR CINGULATE CORTEX, N-ACETYL-ASPARTATE, HUMAN BRAIN, BIOCHEMICAL-ABNORMALITIES, METABOLIC-CHANGES, RTMS, INCREASES, GLUTAMATE
  • Inonu University Affiliated: Yes

Abstract

Objective Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder (MDD). This study evaluated the antidepressant effect of rTMS and examined how it affected N-asetyl aspartate (NAA), choline (Cho), creatine (Cr), lactate (Lac), inyoinositol (mins), glutamate (Glu), glutathione (GSH), and glutamine (Gln) metabolite levels in the left dorsolateral prefrontal cortex (DLPFC) of MDD patients who were not receiving antidepressant medication.