Screening of three ERBB4 gene polymorphisms in a group of Turkish schizophrenia patients and controls


SÖZEN M. M. , KARTALCI Ş.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.40, ss.463-471, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 40 Konu: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1515/tjb-2015-0036
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.463-471

Özet

Objective: The human ERBB4 gene (v-erb-a erithroblastic leukemia viral oncogene homology 4) codes for the ErbB4 receptor protein. One of the ligands of ErbB4 receptor is Neuregulin-1 and it is coded by NRG1 gene which is reported to be a susceptibility gene for schizophrenia. Since ErbB4 receptor is activated by binding of Neuregulin-1, ERBB4 gene is thought to be involved in development of schizophrenia (SZ) as well. Even though several association, expression and animal studies supported this idea and resulted with association between the disease and several single nucleotide polymorphisms (SNP) in the ERBB4 gene, independent studies done in different populations did not replicate that result. In the present study we aimed to get clues about involvement of three ERBB4 SNPs -which were found to be associated with schizophrenia in some other populations- in development of schizophrenia in a group of Turkish patients.