Effects of ethyl 7-hydroxy-2-imino-2H-chromene-3-carboxylate, a synthesized coumarin derivative, on bisphenol A-induced kidney toxicity

AKGÜL, NADİR; Uremis, MUHAMMED; Uremis, Nuray; Annaç, Ebru; BOZAT, RİFAT; Koca, Murat; Özkaya, Ahmet; Yanılmaz, Elif

doi:10.30569/adiyamansaglik.1373918

Effects of ethyl 7-hydroxy-2-imino-2H-chromene-3-carboxylate, a synthesized coumarin derivative, on bisphenol A-induced kidney toxicity

AKGÜL N. B., Uremis M. M., Uremis N., Annaç E., BOZAT R. C., Koca M., ...Daha Fazla

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, cilt.10, sa.1, ss.1-9, 2024 (TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 10 Sayı: 1
Basım Tarihi: 2024
Doi Numarası: 10.30569/adiyamansaglik.1373918
Dergi Adı: Adıyaman Üniversitesi Sağlık Bilimleri Dergisi
Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.1-9
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
İnönü Üniversitesi Adresli: Evet

Özet

Aim: In this study, it was aimed to investigate the protective effect of the synthesized coumarin ethyl 7-hydroxy-2-imino-2H-chromene-3 carboxylate (CM) against the renal toxicity of Bisphenol A (BPA). Materials and Methods: The CM molecule was synthesised through the reaction between 2,4-dihydroxybenzaldehyde and ethyl cyanoacetate. Experiment was conducted in four groups of rats: control, BPA, CM, and BPA+CM. Total Antioxidant Status (TAS), Total Oxidant Status (TOS), and Malondialdehyde (MDA) levels in kidney tissue were evaluated. serum samples were analyzed for Total-Native thiol and kidney function test parameters. Results: The BPA-treated group exhibited significant decreases in TAS and thiol levels, increases in TOS and MDA levels. However, these side effects were significantly reduced with CM. Conclusion: results obtained in this study indicate that CM molecule has a protective effect against BPA induced kidney toxicity.