Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets

Baldauf M. C., Orth M. F., Dallmayer M., Marchetto A., Gerke J. S., Rubio R. A., ...Daha Fazla

ONCOTARGET, cilt.9, sa.2, ss.1587-1601, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.18632/oncotarget.20098
  • Dergi Adı: ONCOTARGET
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1587-1601
  • Anahtar Kelimeler: Ewing sarcoma, Ewing-like sarcoma, immunohistochemistry, BCL11B, GLG1, ROUND-CELL SARCOMAS, TRANSCRIPTION FACTORS, SOFT-TISSUE, EXPRESSION, TUMORS, GENE, FUSION, FAMILY, EWSR1-FLI1, CHROMATIN
  • İnönü Üniversitesi Adresli: Evet

Özet

Ewing sarcoma is an undifferentiated small-round-cell sarcoma. Although molecular detection of pathognomonic EWSR1-ETS fusions such as EWSR1-FLI1 enables definitive diagnosis, substantial confusion can arise if molecular diagnostics are unavailable. Diagnosis based on the conventional immunohistochemical marker CD99 is unreliable due to its abundant expression in morphological mimics.