The analgesic effect of apelin-13 and its mechanism of action within the nitric oxide and serotonin pathways


TURTAY M. G. , KARABAS M., PARLAKPINAR H. , ÇOLAK C. , Sagir M.

HIPPOKRATIA, cilt.19, ss.319-323, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 19 Konu: 4
  • Basım Tarihi: 2015
  • Dergi Adı: HIPPOKRATIA
  • Sayfa Sayıları: ss.319-323

Özet

Background: Apelin has various effects on a lot of systems such as central nervous system and cardiovascular system. This study investigated the possible analgesic effects of apelin-13 using the hot-plate and the tail-flick thermal analgesia tests in rats. We also evaluated the mechanism underlying the analgesic effects of apelin-13 by pretreating with Nw-nitro-L-arginine methyl ester (L-NAME) or ondansetron.