The analgesic effect of apelin-13 and its mechanism of action within the nitric oxide and serotonin pathways

TURTAY M. G., KARABAS M., PARLAKPINAR H., ÇOLAK C., Sagir M.

HIPPOKRATIA, cilt.19, sa.4, ss.319-323, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 4
  • Basım Tarihi: 2015
  • Dergi Adı: HIPPOKRATIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.319-323
  • Anahtar Kelimeler: Apelin-13, analgesic, rat, nitric oxide, serotonin, APJ RECEPTOR, THERMAL HYPERALGESIA, NEUROPATHIC PAIN, RAT MODEL, MICE, LIGAND, EXPRESSION, SECRETION, TRAMADOL
  • İnönü Üniversitesi Adresli: Evet

Özet

Background: Apelin has various effects on a lot of systems such as central nervous system and cardiovascular system. This study investigated the possible analgesic effects of apelin-13 using the hot-plate and the tail-flick thermal analgesia tests in rats. We also evaluated the mechanism underlying the analgesic effects of apelin-13 by pretreating with Nw-nitro-L-arginine methyl ester (L-NAME) or ondansetron.