Structural evaluation in inherited retinal diseases

Varela M. D., ESENER B., Hashem S. A., de Guimaraes T. A. C., Georgiou M., Michaelides M.

BRITISH JOURNAL OF OPHTHALMOLOGY, cilt.105, sa.12, ss.1623-1631, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 105 Sayı: 12
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1136/bjophthalmol-2021-319228
  • Dergi Adı: BRITISH JOURNAL OF OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1623-1631
  • Anahtar Kelimeler: imaging, genetics, clinical trial, retina, dystrophy, OPTICAL COHERENCE TOMOGRAPHY, NEAR-INFRARED AUTOFLUORESCENCE, CONE DENSITY-MEASUREMENTS, VESSEL OXYGEN-SATURATION, FUNDUS AUTOFLUORESCENCE, RETINITIS-PIGMENTOSA, STARGARDT DISEASE, IN-VIVO, VISUAL FUNCTION, ATROPHY SECONDARY
  • İnönü Üniversitesi Adresli: Evet

Özet

Ophthalmic genetics is a field that has been rapidly evolving over the last decade, mainly due to the flourishing of translational medicine for inherited retinal diseases (IRD). In this review, we will address the different methods by which retinal structure can be objectively and accurately assessed in IRD. We review standard-of-care imaging for these patients: colour fundus photography, fundus autofluorescence imaging and optical coherence tomography (OCT), as well as higher-resolution and/or newer technologies including OCT angiography, adaptive optics imaging, fundus imaging using a range of wavelengths, magnetic resonance imaging, laser speckle flowgraphy and retinal oximetry, illustrating their utility using paradigm genotypes with on-going therapeutic efforts/trials.