Determination of the Physicochemical Properties of Piroxicam

ÇELEBİER M., NENNİ M., KAPLAN O., Akgeyik E., Kaynak M. S. , ŞAHİN S.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.17, ss.535-541, 2020 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 17 Konu: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/tjps.galenos.2019.82335
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Sayfa Sayıları: ss.535-541

Özet

Objectives: The aim of this study was to determine the acid dissociation constant (pKa) of piroxicam using high performance liquid chromatography (HPLC) and ultraviolet-visible (UV-Vis) spectrophotometry, and to determine the partition coefficient (Log P), distribution coefficient (Log D), and "Log kw" values of piroxicam using HPLC.