Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats

Soysal H., DOĞAN Z., KAMIŞLI Ö.

NEUROPEPTIDES, cilt.56, ss.1-8, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 56
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.npep.2015.12.001
  • Dergi Adı: NEUROPEPTIDES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-8
  • İnönü Üniversitesi Adresli: Evet

Özet

The role of brain-derived neurotrophic factor (BDNF) is to promote and modulate neuronal responses across neurotransmitter systems in the brain. Therefore, abnormal BDNF signaling may be associated with the pathophysiology of schizophrenia. Low BDNF levels have been reported in brains and serums of patients with psychotic disorders. In the present study, we investigated the effects of antiepileptic drugs on BDNF in developing rats. Pregnant rats Were treated with phenytoin (PHT), lamotrigine (LTG) and folic acid for long-term, all through their gestational periods. Experimental epilepsy (EE) model was applied in pregnant rats.