Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats


Soysal H., DOĞAN Z., KAMIŞLI Ö.

NEUROPEPTIDES, cilt.56, ss.1-8, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 56
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.npep.2015.12.001
  • Dergi Adı: NEUROPEPTIDES
  • Sayfa Sayıları: ss.1-8

Özet

The role of brain-derived neurotrophic factor (BDNF) is to promote and modulate neuronal responses across neurotransmitter systems in the brain. Therefore, abnormal BDNF signaling may be associated with the pathophysiology of schizophrenia. Low BDNF levels have been reported in brains and serums of patients with psychotic disorders. In the present study, we investigated the effects of antiepileptic drugs on BDNF in developing rats. Pregnant rats Were treated with phenytoin (PHT), lamotrigine (LTG) and folic acid for long-term, all through their gestational periods. Experimental epilepsy (EE) model was applied in pregnant rats.