Neuroprotective effect of mexiletine in the central nervous system of diabetic rats


Ates O., Cayli S. R. , Altinoz E., Yucel N. , Kocak A., Tarim O., ...Daha Fazla

MOLECULAR AND CELLULAR BIOCHEMISTRY, cilt.286, ss.125-131, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 286
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1007/s11010-005-9102-6
  • Dergi Adı: MOLECULAR AND CELLULAR BIOCHEMISTRY
  • Sayfa Sayıları: ss.125-131

Özet

Both experimental and clinical studies suggests that oxidative stress plays an important role in the pathogenesis of diabetes mellitus type I and type 2. Hyperglycaemia leads to free radical generation and causes neural degeneration. In the present study we investigated the possible neuroprotective effect of mexiletine against streptozotocin-induced hyperglycaemia in the rat brain and spinal cord.