Neuroprotective effect of mexiletine in the central nervous system of diabetic rats
MOLECULAR AND CELLULAR BIOCHEMISTRY, cilt.286, ss.125-131, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 286
- Basım Tarihi: 2006
- Doi Numarası: 10.1007/s11010-005-9102-6
- Dergi Adı: MOLECULAR AND CELLULAR BIOCHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.125-131
- Anahtar Kelimeler: central nervous system, diabetes mellitus, mexiletine, lipid peroxidation, oxidative damage, streptozotocin, CNS WHITE-MATTER, NITRIC-OXIDE FORMATION, XANTHINE-OXIDASE, OXIDATIVE STRESS, ANOXIC INJURY, NA+ CHANNELS, GENERATION, PROTECT, CORTEX, CELLS
- İnönü Üniversitesi Adresli: Evet
Özet
Both experimental and clinical studies suggests that oxidative stress plays an important role in the pathogenesis of diabetes mellitus type I and type 2. Hyperglycaemia leads to free radical generation and causes neural degeneration. In the present study we investigated the possible neuroprotective effect of mexiletine against streptozotocin-induced hyperglycaemia in the rat brain and spinal cord.