Neuroprotective effect of mexiletine in the central nervous system of diabetic rats


Ates O., Cayli S. R. , Altinoz E., Yucel N., Kocak A., Tarim O., ...More

MOLECULAR AND CELLULAR BIOCHEMISTRY, vol.286, pp.125-131, 2006 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 286
  • Publication Date: 2006
  • Doi Number: 10.1007/s11010-005-9102-6
  • Journal Name: MOLECULAR AND CELLULAR BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.125-131
  • Keywords: central nervous system, diabetes mellitus, mexiletine, lipid peroxidation, oxidative damage, streptozotocin, CNS WHITE-MATTER, NITRIC-OXIDE FORMATION, XANTHINE-OXIDASE, OXIDATIVE STRESS, ANOXIC INJURY, NA+ CHANNELS, GENERATION, PROTECT, CORTEX, CELLS

Abstract

Both experimental and clinical studies suggests that oxidative stress plays an important role in the pathogenesis of diabetes mellitus type I and type 2. Hyperglycaemia leads to free radical generation and causes neural degeneration. In the present study we investigated the possible neuroprotective effect of mexiletine against streptozotocin-induced hyperglycaemia in the rat brain and spinal cord.