The beneficial effects of 18 beta-glycyrrhetinic acid on the experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mouse model
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, vol.40, no.4, pp.344-352, 2018 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 40 Issue: 4
- Publication Date: 2018
- Doi Number: 10.1080/08923973.2018.1490318
- Journal Name: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.344-352
- Keywords: EAE, 18 beta-glycyrrhetinic acid, C57BL/6, multiple sclerosis, TNF-alpha, EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS, GLOBAL CEREBRAL ISCHEMIA/REPERFUSION, MULTIPLE-SCLEROSIS, OXIDATIVE STRESS, NEURONAL DAMAGE, CELL-LINE, MICE, THERAPY, GLYCYRRHIZIN, PATHOGENESIS
- Inonu University Affiliated: Yes
Abstract
Aim: The aim of this study was to investigate the beneficial effects of 18 beta-glycyrrhetinic acid (GA) on the experimental allergic encephalomyelitis (EAE) in C57BL/6 mice. GA is a natural substance found in the root of licorice and is used in traditional Chinese medicine. It has many pharmacological activities such as antioxidant, anti-inflammatory, and anti-cancer effects.