The beneficial effects of 18 beta-glycyrrhetinic acid on the experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mouse model

KAMIŞLI S., ÇİFTÇİ O., TAŞLIDERE A., BAŞAK TÜRKMEN N., Ozcan C.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, cilt.40, sa.4, ss.344-352, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/08923973.2018.1490318
  • Dergi Adı: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.344-352
  • Anahtar Kelimeler: EAE, 18 beta-glycyrrhetinic acid, C57BL/6, multiple sclerosis, TNF-alpha, EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS, GLOBAL CEREBRAL ISCHEMIA/REPERFUSION, MULTIPLE-SCLEROSIS, OXIDATIVE STRESS, NEURONAL DAMAGE, CELL-LINE, MICE, THERAPY, GLYCYRRHIZIN, PATHOGENESIS
  • İnönü Üniversitesi Adresli: Evet

Özet

Aim: The aim of this study was to investigate the beneficial effects of 18 beta-glycyrrhetinic acid (GA) on the experimental allergic encephalomyelitis (EAE) in C57BL/6 mice. GA is a natural substance found in the root of licorice and is used in traditional Chinese medicine. It has many pharmacological activities such as antioxidant, anti-inflammatory, and anti-cancer effects.